| Date | Opponent | Site | Time | Television | Score |
|---|
| 11/4 | MONMOUTH HAWKS | Breslin Center • East Lansing, Michigan | 7:00 PM (EST) | .png) | W 81-57 |
| 11/7 | NIAGARA PURPLE EAGLES | Breslin Center • East Lansing, Michigan | 8:00 PM (EST) | .png) | W 96-60 |
| Champions Classic |
| 11/12 | vs (1) Kansas Jayhawks | State Farm Arena • Atlanta, Georgia | 6:30 PM (EST) | .png) | L 77-69 |
| 11/16 | BOWLING GREEN FALCONS | Breslin Center • East Lansing, Michigan | 6:00 PM (EST) | | W 86-72 |
| 11/19 | SAMFORD BULLDOGS | Breslin Center • East Lansing, Michigan | 8:00 PM (EST) | .png) | W 83-75 |
| Maui Invitational |
| 11/25 | vs Colorado Buffaloes | Lahaina Civic Center • Honolulu, Hawaii | 5:00 PM (EST) | .png) | W 72-56 |
| 11/26 | vs Memphis Tigers | Lahaina Civic Center • Honolulu, Hawaii | 6:00 PM (EST) | | L 71-63 |
| 11/27 | vs (12) North Carolina Tar Heels | Lahaina Civic Center • Honolulu, Hawaii | 9:30 PM (EST) | | W 94-91 (OT) |
| 12/4 | @ Minnesota Golden Gophers | Williams Arena • Minneapolis, Minnesota | 8:30 PM (EST) | | W 90-72 |
| 12/7 | NEBRASKA CORNHUSKERS | Breslin Center • East Lansing, Michigan | 12:00 PM (EST) | | W 89-52 |
| 12/17 | vs Oakland Golden Grizzlies | Little Caesars Arena • Detroit, Michigan | 7:00 PM (EST) | | W 77-58 |
| 12/21 | FLORIDA ATLANTIC OWLS | Breslin Center • East Lansing, Michigan | 2:00 PM (EST) | .png) | W 86-69 |
| 12/30 | WESTERN MICHIGAN BRONCOS | Breslin Center • East Lansing, Michigan | 3:00 PM (EST) | | W 80-62 |
| 1/3 | @ Ohio State Buckeyes | Value City Arena • Columbus, Ohio | 8:00 PM (EST) | .png) | W 69-62 |
| 1/9 | WASHINGTON HUSKIES | Breslin Center • East Lansing, Michigan | 8:00 PM (EST) | | W 88-54 |
| 1/12 | @ Northwestern Wildcats | Welsh-Ryan Arena • Evanston, Illinois | 12:00 PM (EST) | | W 78-68 |
| 1/15 | PENN STATE NITTANY LIONS | Breslin Center • East Lansing, Michigan | 7:30 PM (EST) | | W 90-85 |
| 1/19 | (19) ILLINOIS FIGHTING ILLINI | Breslin Center • East Lansing, Michigan | 12:00 PM (EST) | .png) | W 80-78 |
| 1/25 | vs Rutgers Scarlet Knights | Madison Square Garden • New York, New York | 1:30 PM (EST) | | W 81-74 |
| 1/28 | MINNESOTA GOLDEN GOPHERS | Breslin Center • East Lansing, Michigan | 8:00 PM (EST) | | W 73-51 |
| 2/1 | @ USC Trojans | Galen Center • Los Angeles, California | 4:30 PM (EST) | | L 70-64 |
| 2/4 | @ UCLA Bruins | Pauley Pavilion • Los Angeles, California | 10:00 PM (EST) | | L 63-61 |
| 2/8 | OREGON DUCKS | Breslin Center • East Lansing, Michigan | 12:00 PM (EST) | | W 86-74 |
| 2/11 | INDIANA HOOSIERS | Breslin Center • East Lansing, Michigan | 9:00 PM (EST) | | W 71-67 |
| 2/15 | @ Illinois Fighting Illini | State Farm Center • Champaign, Illinois | 8:00 PM (EST) | | W 79-65 |
| 2/18 | (13) PURDUE BOILERMAKERS | Breslin Center • East Lansing, Michigan | 7:00 PM (EST) | | W 75-66 |
| 2/21 | @ (12) Michigan Wolverines | Crisler Center • Ann Arbor, Michigan | 8:00 PM (EST) | | W 75-62 |
| 2/26 | @ (16) Maryland Terrapins | XFINITY Center • College Park, Maryland | 6:30 PM (EST) | | W 58-55 |
| 3/2 | (11) WISCONSIN BADGERS | Breslin Center • East Lansing, Michigan | 1:30 PM (EST) | | W 71-62 |
| 3/6 | @ Iowa Hawkeyes | Carver-Hawkeye Arena • Iowa City, Iowa | 8:00 PM (EST) | | W 91-84 |
| 3/9 | (17) MICHIGAN WOLVERINES | Breslin Center • East Lansing, Michigan | 12:00 PM (EDT) | | W 79-62 |
| Big Ten Conference Tournament |
| 3/14 | vs (8) Oregon Ducks
| Gainbridge Fieldhouse • Indianapolis, Indiana | 12:00 PM (EDT) | | W 74-64 |
| 3/15 | vs (5) Wisconsin Badgers | Gainbridge Fieldhouse • Indianapolis, Indiana | 1:00 PM (EDT) | | L 77-74 |
| NCAA Tournament - South Regional |
| 3/21 | vs (15) Bryant Bulldogs | Rocket Arena • Cleveland, Ohio | 10:00 PM (EDT) | .png) | W 87-62 |
| 3/23 | vs (10) New Mexico Lobos | Rocket Arena • Cleveland, Ohio | 8:40 PM (EDT) | .png) | W 71-63 |
| 3/28 | vs (6) Ole Miss Rebels | State Farm Arena • Atlanta, Georgia | 7:09 PM (EDT) | | W 73-70 |
| 3/30 | vs (1) Auburn Tigers | State Farm Arena • Atlanta, Georgia | 5:05 PM (EDT) | | - |
| |
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| BOLD = Michigan State Home Games |
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| (#) National Ranking of Opponent |
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| (#) Tournament Seed of Opponent |
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