| Date | Opponent | Site | Time (ET) | Television | Satellite Radio | Score |
|---|
| Champions Classic |
| 11/6 | vs (1) Kansas Jayhawks | Bankers Life Fieldhouse Indianapolis, Indiana | 7:00 PM |  | Sirius 121/80; XM 195/80 | L 92-87 |
| 11/11 | FLORIDA GULF COAST EAGLES | Breslin Center East Lansing, Michigan | 6:00 PM |  | Sirius 109; XM 195 | W 106-82 |
| Las Vegas Invitational |
| 11/14 | LOUISIANA-MONROE WARHAWKS | Breslin Center East Lansing, Michigan | 7:00 PM |  | Sirius 134; XM 196 | W 80-59 |
| 11/18 | TENNESSEE TECH GOLDEN EAGLES | Breslin Center East Lansing, Michigan | 6:00 PM |  | Sirius 134; XM 196 | W 101-33 |
| 11/22 | vs (17) UCLA Bruins | Orleans Arena Paradise, Nevada | 10:00 PM |  | Sirius 105; XM 195 | W 87-67 |
| 11/23 | vs Texas Longhorns | Orleans Arena Paradise, Nevada | 6:30 PM |  | | W 78-68 |
| Big Ten/ACC Challenge |
| 11/27 | @ Louisville Cardinals | KFC Yum! Center Louisville, Kentucky | 7:30 PM | | Sirius 135; XM 196 | L 82-78 (OT) |
| 11/30 | @ Rutgers Scarlet Knights | Louis Brown Athletic Center Piscataway, New Jersey | 6:00 PM | | Sirius 133; XM 196 | W 78-67 |
| 12/3 | (18) IOWA HAWKEYES | Breslin Center East Lansing, Michigan | 6:30 PM | | Sirius 138; XM 201 | W 90-68 |
| 12/8 | @ Florida Gators | Exactech Arena Gainesville, Florida | 12:00 PM |  | Sirius 205; XM 195 | W 63-59 |
| 12/16 | WISCONSINGREEN BAY PHOENIX | Breslin Center East Lansing, Michigan | 5:00 PM | | Sirius 84; XM 84 | W 104-83 |
| 12/21 | OAKLAND GOLDEN GRIZZLIES | Breslin Center East Lansing, Michigan | 7:00 PM | | Sirius 84; XM 84 | W 99-69 |
| 12/29 | NORTHERN ILLINOIS HUSKIES | Breslin Center East Lansing, Michigan | 2:00 PM | | Sirius 78; XM 196 | W 88-60 |
| 1/2 | NORTHWESTERN WILDCATS | Breslin Center East Lansing, Michigan | 8:30 PM | | Sirius 134; XM 195 | W 81-55 |
| 1/5 | @ (12) Ohio State Buckeyes | Value City Arena Columbus, Ohio | 12:00 PM |  | Sirius 105; XM 196 | W 86-77 |
| 1/8 | PURDUE BOILERMAKERS | Breslin Center East Lansing, Michigan | 9:00 PM |  | Sirius 84; XM 84 | W 77-59 |
| 1/13 | @ Penn State Nittany Lions | Bryce Jordan Center University Park, Pennsylvania | 4:30 PM | | Sirius 103; XM 195 | W 71-56 |
| 1/17 | @ Nebraska Cornhuskers | Pinnacle Bank Arena Lincoln, Nebraska | 8:00 PM | | Sirius 84; XM 84 | W 70-64 |
| 1/21 | (13) MARYLAND TERRAPINS | Breslin Center East Lansing, Michigan | 6:30 PM | | Sirius 138; XM 195 | W 69-55 |
| 1/24 | @ (19) Iowa Hawkeyes | Carver-Hawkeye Arena Iowa City, Iowa | 7:00 PM | | Sirius 84; XM 84 | W 82-67 |
| 1/27 | @ Purdue Boilermakers | Mackey Arena West Lafayette, Indiana | 1:00 PM | | Sirius 81; XM 81 | L 73-63 |
| 2/2 | INDIANA HOOSIERS | Breslin Center East Lansing, Michigan | 6:00 PM |  | Sirius 78; XM 210 | L 79-75 (OT) |
| 2/5 | @ Illinois Fighting Illini | State Farm Center Champaign, Illinois | 7:00 PM | | Sirius 134; XM 196 | L 79-74 |
| 2/9 | MINNESOTA GOLDEN GOPHERS | Breslin Center East Lansing, Michigan | 2:00 PM | | Sirius 134; XM 195 | W 79-55 |
| 2/12 | @ (20) Wisconsin Badgers | Kohl Center Madison, Wisconsin | 7:00 PM | | Sirius 99; XM 195 | W 67-59 |
| 2/17 | OHIO STATE BUCKEYES | Breslin Center East Lansing, Michigan | 1:00 PM | | Sirius 84; XM 84 | W 62-44 |
| 2/20 | RUTGERS SCARLET KNIGHTS | Breslin Center East Lansing, Michigan | 6:30 PM | | Sirius 98; XM 195 | W 71-60 |
| 2/24 | @ (7) Michigan Wolverines | Crisler Center Ann Arbor, Michigan | 3:45 PM | | Sirius 81; XM 81 | W 77-70 |
| 3/2 | @ Indiana Hoosiers | Assembly Hall Bloomington, Indiana | 12:00 PM | | Sirius 84; XM 84 | L 63-62 |
| 3/5 | NEBRASKA CORNHUSKERS | Breslin Center East Lansing, Michigan | 7:00 PM | | Sirius 135; XM 195 | W 91-76 |
| 3/9 | (7) MICHIGAN WOLVERINES | Breslin Center East Lansing, Michigan | 8:00 PM | | Sirius 98; XM 195 | W 75-63 |
| Big Ten Conference Tournament |
| 3/15 | vs (8) Ohio State Buckeyes | United Center Chicago, Illinois | 12:30 PM | | Sirius 84; XM 84 | W 77-70 |
| 3/16 | vs (4) Wisconsin Badgers | United Center Chicago, Illinois | 1:00 PM |  | Sirius 84; XM 84 | W 67-55 |
| 3/17 | vs (3) Michigan Wolverines | United Center Chicago, Illinois | 3:30 PM | | Sirius 84; XM 84 | W 65-60 |
| NCAA Tournament - East Regional |
| 3/21 | vs (15) Bradley Braves | Wells Fargo Arena Des Moines, Iowa | 2:45 PM | | Sirius 135; XM 201 | W 76-65 |
| 3/23 | vs (10) Minnesota Golden Gophers | Wells Fargo Arena Des Moines, Iowa | 7:45 PM | | Sirius 135; XM 201 | W 70-50 |
| 3/29 | vs (3) LSU Tigers | Capital One Arena Washington, D.C. | 7:09 PM | | Sirius 135; XM 201 | W 80-63 |
| 3/31 | vs (1) Duke Blue Devils | Capital One Arena Washington, D.C. | 5:05 PM | | Sirius 84; XM 84 | W 68-67 |
| NCAA Tournament - Final Four |
| 4/6 | vs (3) Texas Tech Red Raiders | U.S. Bank Stadium Minneapolis, Minnesota | 8:49 PM | | Sirius 84; XM 84 | L 61-51 |
| |
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| BOLD = Michigan State Home Games |
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| All Times are Eastern |
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| (#) National Ranking of Opponent |
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| (#) Tournament Seed of Opponent |
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