| Date | Opponent | Site | Time (ET) | Television | Satellite Radio | Score |
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| 11/10 | NORTH FLORIDA OSPREYS | Breslin Center • East Lansing, Michigan | 8:00 PM |  | Sirius 134; XM 195 | W 98-66 |
| Champions Classic |
| 11/14 | vs (1) Duke Blue Devils | United Center • Chicago, Illinois | 7:00 PM |  | Sirius 84; XM 84 | L 88-81 |
| PK80–Phil Knight Invitational |
| 11/19 | STONY BROOK SEAWOLVES | Breslin Center • East Lansing, Michigan | 4:00 PM |  | Sirius 84; XM 84 | W 93-71 |
| 11/23 | vs DePaul Blue Demons | Moda Center • Portland, Oregon | 11:30 PM | | Sirius 81; XM 81 | W 73-51 |
| 11/24 | vs Connecticut Huskies | Veterans Memorial Coliseum • Portland, Oregon | 11:59 PM | | | W 77-57 |
| 11/26 | vs (9) North Carolina Tar Heels | Moda Center • Portland, Oregon | 8:30 PM | | | W 63-45 |
| Big Ten/ACC Challenge |
| 11/30 | (5) NOTRE DAME FIGHTING IRISH | Breslin Center • East Lansing, Michigan | 7:00 PM | | Sirius 138; XM 195 | W 81-63 |
| 12/3 | NEBRASKA CORNHUSKERS | Breslin Center • East Lansing, Michigan | 4:30 PM |  | Sirius 135; XM 195 | W 86-57 |
| 12/5 | @ Rutgers Scarlet Knights | Louis Brown Athletic Center • Piscataway, New Jersey | 7:00 PM | | Sirius 83; XM 83 | W 62-52 |
| 12/9 | SOUTHERN UTAH THUNDERBIRDS | Breslin Center • East Lansing, Michigan | 6:00 PM | | Sirius 135; XM 195 | W 88-63 |
| Hitachi College Basketball Showcase |
| 12/16 | vs Oakland Golden Grizzlies | Little Caesars Arena • Detroit, Michigan | 2:30 PM |  | Sirius 119; XM 196 | W 86-73 |
| 12/18 | HOUSTON BAPTIST HUSKIES | Breslin Center • East Lansing, Michigan | 6:00 PM | | Sirius 137; XM 195 | W 107-62 |
| 12/21 | LONG BEACH STATE 49ERS | Breslin Center • East Lansing, Michigan | 7:00 PM |  | Sirius 83; XM 83 | W 102-60 |
| 12/29 | CLEVELAND STATE VIKINGS | Breslin Center • East Lansing, Michigan | 6:00 PM | | Sirius 137 | W 111-61 |
| 12/31 | SAVANNAH STATE TIGERS | Breslin Center • East Lansing, Michigan | 12:00 PM | | Sirius 145; XM 195 | W 108-52 |
| 1/4 | MARYLAND TERRAPINS | Breslin Center • East Lansing, Michigan | 8:00 PM | | Sirius 84; XM 84 | W 91-61 |
| 1/7 | @ Ohio State Buckeyes | Value City Arena • Columbus, Ohio | 4:30 PM |  | Sirius 135; XM 195 | L 80-64 |
| 1/10 | RUTGERS SCARLET KNIGHTS | Breslin Center • East Lansing, Michigan | 7:00 PM | | Sirius 145; XM 195 | W 76-72 (OT) |
| 1/13 | MICHIGAN WOLVERINES | Breslin Center • East Lansing, Michigan | 12:00 PM |  | Sirius 84; XM 84 | L 82-72 |
| 1/19 | INDIANA HOOSIERS | Breslin Center • East Lansing, Michigan | 7:00 PM | | Sirius 81; XM 81 | W 85-57 |
| 1/22 | @ Illinois Fighting Illini | State Farm Center • Champaign, Illinois | 9:00 PM | | Sirius 81; XM 81 | W 87-74 |
| 1/26 | WISCONSIN BADGERS | Breslin Center • East Lansing, Michigan | 8:00 PM | | Sirius 83; XM 83 | W 76-61 |
| 1/28 | @ Maryland Terrapins | XFINITY Center • College Park, Maryland | 1:00 PM | | Sirius 84; XM 84 | W 74-68 |
| 1/31 | PENN STATE NITTANY LIONS | Breslin Center • East Lansing, Michigan | 6:30 PM | | Sirius 138; XM 195 | W 76-68 |
| 2/3 | @ Indiana Hoosiers | Assembly Hall • Bloomington, Indiana | 8:15 PM |  | Sirius 135; XM 195 | W 63-60 |
| 2/6 | @ Iowa Hawkeyes | Carver-Hawkeye Arena • Iowa City, Iowa | 9:00 PM | | Sirius 81; XM 81 | W 96-93 |
| 2/10 | (3) PURDUE BOILERMAKERS | Breslin Center • East Lansing, Michigan | 4:00 PM | | Sirius 84; XM 84 | W 68-65 |
| 2/13 | @ Minnesota Golden Gophers | Williams Arena • Minneapolis, Minnesota | 9:00 PM |  | Sirius 80/135; XM 80/195 | W 87-57 |
| 2/17 | @ Northwestern Wildcats | Allstate Arena • Rosemont, Illinois | 2:00 PM | | Sirius 84; XM 84 | W 65-60 |
| 2/20 | ILLINOIS FIGHTING ILLINI | Breslin Center • East Lansing, Michigan | 7:00 PM | | Sirius 84; XM 84 | W 81-61 |
| 2/25 | @ Wisconsin Badgers | Kohl Center • Madison, Wisconsin | 1:00 PM | | Sirius 84; XM 84 | W 68-63 |
| Big Ten Conference Tournament |
| 3/2 | vs (9) Wisconsin Badgers | Madison Square Garden • New York, New York | 12:00 PM | | Sirius 134; XM 195 | W 63-60 |
| 3/3 | vs (5) Michigan Wolverines | Madison Square Garden • New York, New York | 2:00 PM |  | Sirius 134; XM 195 | L 75-64 |
| NCAA Tournament - Midwest Regional |
| 3/16 | vs (14) Bucknell Bison | Little Caesars Arena • Detroit, Michigan | 7:10 PM | | Sirius 138; XM 202 | W 82-78 |
| 3/18 | vs (11) Syracuse Orange | Little Caesars Arena • Detroit, Michigan | 2:40 PM | | Sirius 137; XM 201 | L 55-53 |
| |
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| BOLD = Michigan State Home Games |
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| All Times are Eastern |
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| (#) National Ranking of Opponent |
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| (#) Tournament Seed of Opponent |
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